COG1410, ApoE Mimetic Peptide

COG1410 ApoE Mimetic Peptide | Neuroprotective & Anti-Inflammatory Research Peptide

Product Name: COG1410
 Synonym: ApoE Mimetic Peptide
 CAS Number: 878009-24-6
 Molecular Formula: C₆₄H₁₂₁N₂₁O₁₄
 Molecular Weight: 1408.78 g/mol
 Sequence: Ac-AS-{Aib}-LRKL-{Aib}-KRLL-NH₂
 Purity: ≥98%
 Appearance: Solid, white to off-white

What is COG1410?

COG1410 ApoE mimetic peptide is a synthetic peptide derived from the receptor-binding region of apolipoprotein E (ApoE). It is structurally enhanced with alpha-aminoisobutyric acid (Aib) residues for increased stability and bioactivity. This research peptide is known for its neuroprotective and anti-inflammatory effects, making it ideal for preclinical investigation into brain health, traumatic brain injury (TBI), stroke, and neurodegenerative diseases.

COG1410 Peptide Anti-Inflammatory Uses

●     Neuroinflammation Reduction: COG1410 has demonstrated the ability to modulate inflammation in brain tissues following traumatic brain injury and ischemic events.

●     Oxidative Stress Control: It reduces oxidative damage and cellular apoptosis in neuronal environments.

●     Cognitive Recovery Support: Shows promise in improving neurological outcomes post-TBI in animal models.

●     Immunomodulatory Effects: Helps balance pro- and anti-inflammatory cytokines in the central nervous system.

COG1410 for Brain Health Research

Used extensively in neurological research, COG1410 plays a key role in investigating:

●      Traumatic Brain Injury (TBI)

●      Cerebral ischemia and stroke

●      Alzheimer’s and neurodegenerative conditions

●      Neuroimmune interactions

Its design enables crossing of the blood-brain barrier, a vital feature for brain-targeted therapeutic research.

COG1410 vs COG112 Peptide Comparison

While both peptides are derived from ApoE and share anti-inflammatory and neuroprotective characteristics:

●     COG112 includes a cell-penetrating peptide (CPP) sequence to enhance intracellular delivery.

●     COG1410, with its Aib-modified backbone, offers increased resistance to enzymatic degradation and sustained bioactivity.

Researchers may choose COG1410 for longer-lasting effects and targeted action in neuroinflammatory models.

Storage & Handling

●      Powder:

○        −80°C: 3 years

○        −20°C: 2 year

●      In Solution (sealed, nitrogen-protected):

○        −80°C: 1 year

○        −20°C: 6 months

●     Shipping: Room temperature (within continental US)

Specifications

Where to Buy COG1410 Peptide

Where to buy COG1410 peptide online? We provide high-purity, research-grade COG1410 ApoE mimetic peptide, available in bulk or small quantities for laboratories, universities, and R&D professionals. Ideal for formulations in brain injury, stroke, and neuroinflammation research.