COG112, ApoE Mimetic Peptide
COG112, ApoE Mimetic Peptide
COG112 ApoE Mimetic Peptide | Anti-Inflammatory & Neuroprotective Research Peptide
Product Overview:
COG112 is a synthetic Apolipoprotein E (ApoE) mimetic peptide designed by conjugating the receptor-binding domain of ApoE (COG133) with the cell-penetrating peptide (CPP) antennapedia (Antp). This modification significantly enhances the peptide’s anti-inflammatory properties and neuroprotective effects compared to COG133 alone.
Sequence:
acetyl-YRQIKIWFQNRRMKWKKCLRVRLASHLRKLRKRLL-amide
Molecular Formula:
C202H347N71O38S2
Molecular Weight:
4460.51 g/mol
Key Features and Uses:
● ApoE mimetic peptide COG112 is extensively studied for its ability to modulate inflammatory responses, primarily by inhibiting the NF-κB signaling pathway.
●Exhibits potent anti-inflammatory properties useful for research into neurodegenerative diseases and inflammatory bowel disease.
● Compared to the original ApoE peptide COG133, COG112 demonstrates enhanced cell penetration and therapeutic efficacy due to the CPP antennapedia conjugation.
● Recent research highlights the role of COG112 in cancer biology by inhibiting the SET-Rac1 interaction, resulting in decreased cancer cell migration and invasion.
● COG112 peptide is widely used in anti-inflammatory uses and ApoE peptide research studies to explore novel therapeutic applications.
Research Insights:
● COG112 vs COG133 ApoE peptide: The addition of the CPP domain in COG112 dramatically improves cellular uptake and anti-inflammatory activity compared to COG133 alone, making it a superior candidate for experimental therapies targeting inflammation and neuroprotection.
●Potential applications include modulation of inflammatory bowel disease, neurodegenerative disorders such as Alzheimer’s disease, and oncology research focused on tumor invasion and metastasis.
Product Applications:
Ideal for scientists and researchers investigating:
● Inflammatory signaling pathways (e.g., NF-κB inhibition)
● Neuroprotection mechanisms
● Cancer cell migration and invasion pathways
● Novel peptide therapeutics development
CAS #: NA