{"product_id":"n-acetyl-semax","title":"N-Acetyl Semax","description":"\u003cp\u003e\u003cstrong\u003eN-Acetyl Semax\u003c\/strong\u003e is a synthetic polypeptide analogous to the naturally occurring adrenocorticotropic hormone (ACTH). The peptide is similar to a fragment from the adrenocorticotropic hormone ACTH (4-7), specifically Met-Glu-His-Phe, combined with a Pro-Gly-Pro extension at the C-terminus.\u003csup\u003e(1)\u003c\/sup\u003e The addition of Pro-Gly-Pro (PGP) to \u003cstrong\u003eN-Acetyl Semax\u003c\/strong\u003e might enable an enhanced permeability through the blood-brain barrier (BBB) by increasing the peptide's lipophilicity via improving passive diffusion or uptake via lipid raft-mediated endocytosis, which may potentially allow it to bypass the tight junctions of the BBB. The PGP addition at the C-terminus might also alter the peptide's interaction with specific BBB transporters or receptors, possibly promoting receptor-mediated transcytosis. Additionally, the acetylation of the peptide might increase its resistance to enzymatic degradation, prolonging its half-life in experimental models.\u003c\/p\u003e\n\u003ch3\u003eOverview\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eN-Acetyl Semax\u003c\/strong\u003e appears to exhibit potential nootropic (memory enhancing) and neuroprotective characteristics, which researchers have proposed may be produced via several routes:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eBy potentially interacting with dopamine, serotonin, enkephalin, and brain-derived neurotrophic (BDNF) levels;\u003csup\u003e(2)(3)\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eOr by potentially modulating gene expression and increasing the efficacy of the immune system.\u003csup\u003e(4)\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eBased on studies suggesting that the peptide may inhibit serum enkephalin-degrading enzymes, it is plausible to hypothesize about the interactions between Semax and enkephalins. Researchers suggest Semax's inhibitory potential on enkephalin-degrading enzymes may lead to an increase in the levels of enkephalins by preventing their degradation. Enkephalins are endogenous opioids that are considered to play roles in nociception and stress response. Further, an increase in enkephalin levels might also influence other neurotransmitter systems due to the complex interplay between the opioid system and neurotransmitters like dopamine and serotonin.\u003csup\u003e(2)\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003eAccording to studies, Semax may potentially increase the striatal levels of 5-hydroxyindoleacetic acid (5-HIAA), a serotonin metabolite, suggesting a possible enhancement of serotonergic activity. This potential action on serotonin metabolism might amplify serotonin-mediated pathways, possibly influencing central nervous system functioning. On the other hand, Semax does not appear to directly alter dopamine levels or its metabolites. Still, it may modulate the dopaminergic system's responsiveness, enhancing the dopaminergic agonists' action.\u003csup\u003e(5)\u003c\/sup\u003e\u003c\/p\u003e\n\u003ch3\u003eChemical Info\u003csup\u003e(6)\u003c\/sup\u003e\n\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C\u003csub\u003e37\u003c\/sub\u003eH\u003csub\u003e51\u003c\/sub\u003eN\u003csub\u003e9\u003c\/sub\u003eO\u003csub\u003e10\u003c\/sub\u003eS\u003cbr\u003e\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 858.97 g\/mol\u003cbr\u003e\u003cstrong\u003eSynonyms:\u003c\/strong\u003e ACTH (4-7)PGP, HY-P1146\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2\u003eResearch and Clinical Studies\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eN-Acetyl Semax and Nootropic Potential\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eA study\u003csup\u003e(5)\u003c\/sup\u003e was conducted on experimental rodents to determine the nootropic potential of ACTH hormone and its analogs, such as Semax. After exposure to Semax, all tested rodents were examined for 5-hyrodxyindoleacetic acid (5-HIAA) levels. Based on the results, it was noted that the 5-HIAA levels increased by 25% after just 2 hours following exposure; they increased progressively up to a maximum of 180% after 4 hours. As per Kirill O Eremin \u003cem\u003eet al., “Our results reveal the positive modulatory [action] of Semax on the striatal serotonergic system and the ability of Semax to enhance both the striatal release of dopamine and locomotor behavior elicited by D-amphetamine.”\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eIn another research study,\u003csup\u003e(7) \u003c\/sup\u003eexperimental models under excessive stress conditions were exposed to Semax. Upon analyzing behavior 24 hours after peptide exposure, it was noted that they appeared to show signs of enhanced memory and attention. As per the reports, \u003cem\u003e\"In the majority of cases, the peptide exhibited positive [actions], and in no case did it produce negative side actions or complications connected with its administration. There is good reason to believe that … potentialities of Semax have not been exhausted and in the future new possibilities … will be revealed.\"\u003c\/em\u003e The study is shared here for educational and research purposes, and studies on the Semax peptide are still being conducted.\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eN-Acetyl Semax and SSRI Interaction\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eSelective Serotonin reuptake inhibitors (SSRIs) are a class of antidepressants. In pregnant research models, the compounds may risk passing through the placenta and impacting fetal brain development. In a preclinical research study,\u003csup\u003e(8)\u003c\/sup\u003e experimental rats aged between 1 and 14 days were presented first with an SSRI compound, followed by the Semax peptide. After 4 weeks, it was observed that the rats exposed to SSRIs showcased anxious behavior, especially when exposed to new stimuli. When they were given the Semax peptide, these same rats later reportedly exhibited a reduction in their anxiety levels and potential enhancement in their learning abilities.\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eN-Acetyl Semax and Separation Anxiety\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eYoung offspring face separation anxiety when they are away from their mothers. Separating for a prolonged period may lead to impaired emotional reactivity. A research study\u003csup\u003e(9)\u003c\/sup\u003e examined young rats facing maternal deprivation. After four weeks of separation from their mothers, these rats reportedly exhibited increased anxiety and excessive physical activity. When the rats were presented with Semax, their reactions improved, indicating reduced anxiety. As per M. A. Volodina \u003cem\u003eet al., \u003c\/em\u003ethese results suggest that “\u003cem\u003eSemax [weakens] the impact of deprivation on animal body weight and [normalizes] the levels of anxiety in rats\u003c\/em\u003e.”\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eN-Acetyl Semax and the Cardiovascular System\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eFor this study,\u003csup\u003e(10)\u003c\/sup\u003e rodents were induced with myocardial infarction (MI), which may lead to vascular damage. These rodents were then divided into two groups – one was given \u003ca href=\"https:\/\/www.corepeptides.com\/peptides\/semax-25mg\/\" title=\"Semax for sale - 25mg\"\u003eSemax peptide\u003c\/a\u003e for six days, and the second was given a placebo. Following 28 days after the occurrence of myocardial infarction, it was reported by the researchers that the control rodents appeared to exhibit reduced arterial blood pressure and cardiac hypertrophy, both of which may signal impending heart failure. In contrast, the peptide-exposed rodents reportedly exhibited signs of prevention of diastolic blood pressure, which may indicate possible remodeling of the heart ventricle and inhibition of heart failure.\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eN-Acetyl Semax and Neuroprotection\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eIn a clinical study,\u003csup\u003e(11)\u003c\/sup\u003e research models of ischemic strokes were evaluated for 10 days. Of these, 30% were presented with conventional compounds and the Semax peptide, while the remaining 70% were presented with conventional compounds only. After 10 days, all models were examined via electroencephalogram (EEG). Based on the EEG mapping, the researchers reported that the experimental group exposed to both the peptide and compound exhibited apparently notable improvement in restoring damaged brain activity.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eN-Acetyl Semax peptide is available for research and laboratory purposes only. Please review and adhere to our Terms and Conditions before ordering.\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003ch3\u003eReferences\u003c\/h3\u003e\n\u003col\u003e\n\u003cli\u003eT. Kolomin et al., A New Generation of Drugs: Synthetic Peptides based on Natural Regulatory peptides. Neuroscience \u0026amp; Medicine, 2013, 223-252. Published Online December 2013. \u003ca href=\"https:\/\/dx.doi.org\/10.4236\/nm.2013.44035\" rel=\"noopener\" target=\"_blank\"\u003ehttp:\/\/dx.doi.org\/10.4236\/nm.2013.44035\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eKost NV, Sokolov OIu, Gabaeva MV, Grivennikov IA, Andreeva LA, Miasoedov NF, Zozulia AA. Ingibiruiushchee deĭstvie semaksa i selanka na énkefalindegradiruiushchie fermenty syvorotki krovi cheloveka [Semax and selank inhibit the enkephalin-degrading enzymes from human serum]]. Bioorg Khim. 2001 May-Jun;27(3):180-3. Russian. doi: 10.1023\/a:1011373002885. PMID: 11443939. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11443939\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/11443939\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eShih-Jen Tsai, Semax, an analogue of adrenocorticotropin (4–10), is a potential agent for the treatment of attention-deficit hyperactivity disorder and Rett syndrome, Medical Hypotheses, Volume 68, Issue 5, 2007, Pages 1144-1146. \u003ca href=\"https:\/\/doi.org\/10.1016\/j.mehy.2006.07.017\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/doi.org\/10.1016\/j.mehy.2006.07.017\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eMedvedeva, E.V., Dmitrieva, V.G., Povarova, O.V. et al. The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis. BMC Genomics 15, 228 (2014). \u003ca href=\"https:\/\/doi.org\/10.1186\/1471-2164-15-228\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/doi.org\/10.1186\/1471-2164-15-228\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eEremin KO, Kudrin VS, Saransaari P, Oja SS, Grivennikov IA, Myasoedov NF, Rayevsky KS. Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents. Neurochem Res. 2005 Dec;30(12):1493-500. doi: 10.1007\/s11064-005-8826-8. PMID: 16362768. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16362768\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/16362768\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eNational Center for Biotechnology Information (2023). PubChem Compound Summary for CID 9811102, Semax.\u003c\/li\u003e\n\u003cli\u003eAsmarin IP, Nezavibat'ko VN, Miasoedov NF, Kamenskiĭ AA, Grivennikov IA, Ponomareva-Stepnaia MA, Andreeva LA, Kaplan AIa, Koshelev VB, Riasina TV. Nootropnyĭ analog adrenokortikotropina 4-10-semaks (15-letniĭ opyt razrabotki i izucheniia) [A nootropic adrenocorticotropin analog 4-10-semax (l5 years experience in its design and study)]. Zh Vyssh Nerv Deiat Im I P Pavlova. 1997 Mar-Apr;47(2):420-30. Russian. PMID: 9173745. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9173745\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/9173745\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eNataliya Yu. Glazova, Daria M. Manchenko, Maria A. Volodina, Svetlana A. Merchieva, Ludmila A. Andreeva, Vladimir S. Kudrin, Nikolai F. Myasoedov, Natalia G. Levitskaya, Semax, synthetic ACTH(4–10) analog, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats, Neuropeptides, Volume 86, 2021, 102114, ISSN 0143-4179. \u003ca href=\"https:\/\/doi.org\/10.1016\/j.npep.2020.102114\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/doi.org\/10.1016\/j.npep.2020.102114\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eVolodina MA, Sebentsova EA, Glazova NY, Levitskaya NG, Andreeva LA, Manchenko DM, Kamensky AA, Myasoedov NF. Semax attenuates the influence of neonatal maternal deprivation on the behavior of adolescent white rats. Bull Exp Biol Med. 2012 Mar;152(5):560-3. English, Russian. doi: 10.1007\/s10517-012-1574-2. PMID: 22803132. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22803132\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/22803132\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eGavrilova SA, Golubeva AV, Lipina TV, Fominykh ES, Shornikova MV, Postnikov AB, Andrejeva LA, Chentsov IuS, Koshelev VB. [Protective effect of peptide semax (ACTH(4-7)Pro-Gly-Pro) on the rat heart rate after myocardial infarction]. Ross Fiziol Zh Im I M Sechenova. 2006 Nov;92(11):1305-21. Russian. PMID: 17385423. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17385423\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/17385423\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eGusev EI, Skvortsova VI, Miasoedov NF, Nezavibat'ko VN, Zhuravleva EIu, Vanichkin AV. Effektivnost' semaksa v ostrom periode polusharnogo ishemicheskogo insul'ta (klinicheskoe i élektrofiziologicheskoe issledovanie) [Effectiveness of semax in acute period of hemispheric ischemic stroke (a clinical and electrophysiological study)]. Zh Nevrol Psikhiatr Im S S Korsakova. 1997;97(6):26-34. Russian. PMID: 11517472. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11517472\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/11517472\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"QUALITIDE","offers":[{"title":"Default Title","offer_id":50103643963638,"sku":"QT-2101-20MG","price":59.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0797\/4849\/7654\/files\/QT-2101_Selank-20mg.png?v=1773334058","url":"https:\/\/triskly.com\/products\/n-acetyl-semax","provider":"Triskly","version":"1.0","type":"link"}